Informazioni sul sito:

Nome del dominio - mtep.it

Titolo del sito - M.T.& P. On Line

Vai al sito web - M.T.& P. On Line

Posizione GEO del sito

Posizione Paese - Italy

Fornitore - ITnet S.r.l.

Site Logo

indirizzo IP:

151.1.48.10

Server dei nomi di dominio:

dns3.it.net ns1.it.net

Tutti i record:

☆ mtep.it. 21600 IN SOA ns1.it.net. postmaster.ns1.it.net. 2012060104 28800 7200 604800 86400
☆ mtep.it. 21600 IN NS dns3.it.net.
☆ mtep.it. 21600 IN NS ns1.it.net.
☆ mtep.it. 300 IN MX 10 mailin01.it.net.
☆ mtep.it. 21600 IN A 151.1.48.10

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Domain: mtep.it
Status: ok
Signed: no
Created: 2006-02-23 00:00:00
Last Update: 2024-03-10 01:02:57
Expire Date: 2025-02-23

Registrant
Organization: M.T.&P. SRL
Address: Via De Gasperi, 85
Rho
20017
MI
IT
Created: 2007-03-01 10:43:25
Last Update: 2012-09-07 10:40:10

Admin Contact
Name: Andrea De Bernardi
Address: Via De Gasperi, 85
Rho
20017
MI
IT
Created: 2006-02-21 00:00:00
Last Update: 2011-12-19 16:55:15

Technical Contacts
Name: Andrea De Bernardi
Address: Via De Gasperi, 85
Rho
20017
MI
IT
Created: 2006-02-21 00:00:00
Last Update: 2011-12-19 16:55:15

Name: Staff Webresidence
Address: Via Jervis, 77
Ivrea
10015
TO
IT
Created: 2007-01-25 00:00:00
Last Update: 2011-12-19 16:55:26

Registrar
Organization: ITnet s.r.l.
Name: ITNET-REG
Web: https://www.it.net
DNSSEC: no


Nameservers
ns1.it.net
dns3.it.net

Brief facts about mtep:

3-pyridine is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for newer and even more improved drugs. MTEP is both more potent and more selective than MPEP as a mGluR5 antagonist, and produces similar neuroprotective, antidepressant, analgesic, and anxiolytic effects but with either similar or higher efficacy depending on the test used. MTEP also has similar efficacy to MPEP in reducing the symptoms of morphine withdrawal, and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration, and also decreasing the addictive effects of nicotine, cocaine and methamphetamine.

MPEP - 2-Methyl-6-pyridine is a research drug which was one of the first compounds found to act as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5.

MFZ 10-7 - MFZ 10-7 is a drug with potential applications in the treatment of addiction, which acts as a negative allosteric modulator of the metabotropic glutamate receptor subtype 5.

Fenobam - Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain.

MGlu5 receptor antagonists

Thiazoles