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Brief facts about cyclam:

Cyclam is an organic compound with the formula₂. Classified as an aza-crown ether, it is a white solid that is soluble in water. As a macrocyclic ligand, it binds strongly to many transition metal cations. The compound was first prepared by the reaction of 1,3-dibromopropane and ethylenediamine. The compound features four secondary amines. Its complexes therefore can exist as several diastereomers, depending on the relative orientation of the N–H centres. Its complexes feature alternating five- and six-membered chelate rings. The closely related ligand cyclen forms only five-membered C₂N₂M chelate rings and tends not to form square-planar complexes.

Sarcophagine - Sarcophagine is a bicyclic cage-like metal chelator molecule. derived from cyclam. Chemical formula of sarcophagine is 3,6,10,13,16,19-hexaazabicycloicosane and additional functional groups are often linked to this structure, such as in DiAmSar.

Plerixafor - Plerixafor is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are then extracted from the blood and transplanted back to the patient. The drug was developed by AnorMED, which was subsequently bought by Genzyme.

Polyamines

Macrocycles

Chelating agents

Nitrogen heterocycles